This is a summary of the most important
information about Zoloft. For details, talk to your healthcare
Zoloft is in a class of medicines called selective serotonin
reuptake inhibitors (SSRIs). Zoloft is used to treat:
Obsessive-compulsive disorder (OCD)
Posttraumatic stress disorder (PTSD)
Premenstrual dysphoric disorder (PMDD)
Social anxiety disorder (SAD)
Never take Zoloft if you are taking another drug used to treat
depression, called a Monoamine Oxidase Inhibitor (MAOI), or if
you have stopped taking an MAOI in the last 14 days. Taking
Zoloft close in time to an MAOI can result in serious,
sometimes fatal, reactions, including:
- High body temperature
- Seizures (convulsions)
MAOI drugs include Nardil (phenelzine sulfate), Parnate
(tranylcypromine sulfate), Marplan (isocarboxazid), and other brands.
Never take Zoloft if you are taking Orap
(pimozide), a drug used to treat Tourette’s
disorder, because it can result in serious heart beat
Never take Zoloft oral concentrate if you are taking
Antabuse (disulfiram), used to treat alcoholism,
because Zoloft oral concentrate contains alcohol.
Suicidal thoughts or actions: See FDA Alert.
Stopping Zoloft: Do not stop taking Zoloft
suddenly because you could get side effects. Your
healthcare professional will slowly decrease your
Bleeding problems: Zoloft may cause bleeding
problems, especially if taken with aspirin, NSAIDs
(nonsteroidal anti-inflammatory drugs, such as
ibuprofen or naproxen), or other drugs that affect
Mania: You may become unusually hyperactive,
excitable or elated.
Seizures: You may experience a seizure
(convulsion), even if you are not taking Zoloft close
in time with a MAOI.
Weight loss: Zoloft can cause weight loss.
Children who take it for a long time should have their
growth and body weight measured regularly.
Pregnancy: Tell your healthcare professional if
you are, or may be, pregnant because babies delivered
to mothers taking Zoloft late in pregnancy have
developed problems, such as difficulty breathing and
Sexual problems: You may have problems with
impotence (erectile dysfunction), abnormal ejaculation,
difficulty reaching orgasm, or decreased libido (sexual
Other side effects include nausea,
diarrhea, difficulty sleeping, dry mouth, and
Tell your healthcare professional about all your
medical conditions, especially if you have liver or
heart disease. Tell your healthcare professional if you
are breast-feeding or plan to breast-feed your
Zoloft may interact with medicines other than the ones already
mentioned in this information sheet. These interactions can
cause serious side effects. Tell your healthcare professional
about all medicines, vitamins, and herbal supplements you take,
Zoloft is taken by mouth, with or without food, once a day.
Dilute Zoloft oral concentrate, but
only in ½ cup of water, ginger ale,
lemon/lime soda, lemonade or orange juice. Take
immediately after mixing. Tell your doctor if you are
allergic to latex because the dropper to measure Zoloft
oral concentrate contains natural rubber.
FDA ALERT [07/2005]: Suicidal Thoughts
or Actions in Children and Adults Patients with depression or
other mental illnesses often think about or attempt suicide.
Closely watch anyone taking antidepressants, especially early
in treatment or when the dose is changed.
Patients who become irritable or anxious, or have new or
increased thoughts of suicide or other changes in mood or
behavior (or their care givers) should contact their healthcare
professional right away.
Taking antidepressants may increase suicidal thoughts and
actions in about 1 out of 50 people 18 years or younger. FDA
has approved Zoloft for use in children only if they have
Several recent scientific publications report the
possibility of an increased risk for suicidal behavior in
adults who are being treated with antidepressant medications.
Even before these reports became available, FDA began a
complete review of all available data to determine whether
there is an increased risk of suicidal thinking or behavior in
adults being treated with antidepressant medications.
It is expected that this review will take a year or longer
to complete. In the meantime, FDA is highlighting that adults
being treated with antidepressant medication, particularly
those being treated for depression, should be watched closely
for worsening of depression and for increased suicidal thinking
information reflects FDA’s preliminary analysis of data
concerning this drug. FDA is considering, but has not reached a
final conclusion about, this information.
Reference for Zoloft Article
U.S. Food and Drug Administration
The National Cancer
The National Eye Institute
The National Heart, Lung, and Blood
National Institute on Aging
National Institute of Allergy and
National Institute of Arthritis and
Musculoskeletal and Skin Diseases
National Institute of Diabetes and
Digestive and Kidney Diseases
National Institute on Drug
National Institute of Mental
National Institute of Neurological
Disorders and Stroke